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Check Intently (two)pentobarbital will reduce the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Robust CYP3A4 inducers could lessen suvorexant efficacy; if elevated suvorexant dose essential, do not exceed twenty mg/working daypentobarbital will lower the level or result of repaglinide